Andre and Jordan Ayew were both on target as 10-man Ghana were forced to settle for a draw against Benin at the Africa Cup of Nations.
Mickael Pote gave Benin a shock lead after two minutes but Black Stars captain Andre Ayew restored parity.
His younger brother Jordan fired Ghana ahead, but Pote earned the Squirrels a point after John Boye was dismissed for a second yellow card.
Cameroon defeated Guinea-Bissau 2-0 in Group F’s other game on Tuesday.
Ghana arrived in Egypt as one of the favourites for the title but were carved open for Benin’s opener, which came from the first real attack of the contest.
Veteran striker Pote, who scored 16 goals in 33 league appearances for Turkish club Adana Demirspor last season, beat two defenders before prodding the ball beyond onrushing goalkeeper Richard Ofori.
The Black Stars’ response was almost immediate, though, the elder Ayew brother finding the bottom corner with a deflected drive from the edge of the penalty box.
Jordan Ayew, who spent the 2018-19 season on loan at Crystal Palace from Swansea City, capitalised on a lapse in concentration from Olivier Verdun to put Ghana ahead, before Boye – who had been booked in the first half – was shown a second yellow card for time-wasting.
Benin soon made their numerical advantage count, Pote firing home his second of the game following a well-worked corner to earn the Squirrels their second ever point in the tournament.
Four-time winners Ghana return to action against Cameroon on Saturday evening (18:00 BST), while Benin face Guinea-Bissau in the day’s late game.
Analysis
BBC World Service’s Ben Sutherland in Cairo
The Ayew brothers have been Ghana’s twin talismen for three Afcons now, but Benin gave them a chastening reminder that they can’t do everything themselves.
Benin’s shock early goal was a result of nothing less than Ghana throwing down a red cloak and inviting them to put the ball into their goal.
Then the Ayew brothers set to work, hauling Ghana into the winning position they were expecting – only for a lack of discipline to cost them, as Boye was sent off before another defensive lapse let Pote get his second.
Benin were constantly at Ghana and really could have won it at the death. Holders Cameroon might well walk away with this group, but the fight for second place is now set up very nicely indeed.
Live Text
Match ends, Ghana 2, Benin 2.
Second Half ends, Ghana 2, Benin 2.
Attempt missed. Steve Mounie (Benin) header from the centre of the box is just a bit too high. Assisted by Jodel Dossou with a cross.
Steve Mounie (Benin) is shown the yellow card.
Substitution, Ghana. Afriyie Acquah replaces André Ayew.
Foul by Jordan Adeoti (Benin).
Jordan Ayew (Ghana) wins a free kick in the defensive half.
Attempt missed. Jordan Adeoti (Benin) right footed shot from outside the box is high and wide to the right. Assisted by David Djigla.
Attempt blocked. Jodel Dossou (Benin) left footed shot from the right side of the box is blocked. Assisted by Emmanuel Imorou with a cross.
Corner, Ghana. Conceded by Seidou Barazé.
Attempt saved. David Djigla (Benin) right footed shot from outside the box is saved in the centre of the goal. Assisted by Mickaël Poté with a headed pass.
Substitution, Benin. David Djigla replaces Cebio Soukou.
Andy Yiadom (Ghana) wins a free kick in the defensive half.
Foul by Mickaël Poté (Benin).
Foul by Andy Yiadom (Ghana).
Mickaël Poté (Benin) wins a free kick in the defensive half.
Mubarak Wakaso (Ghana) wins a free kick in the defensive half.
Foul by Steve Mounie (Benin).
Mubarak Wakaso (Ghana) wins a free kick in the defensive half.
Foul by Mama Seibou (Benin).
Andy Yiadom (Ghana) wins a free kick on the right wing.
Foul by Jodel Dossou (Benin).
Kasim Adams (Ghana) is shown the yellow card for a bad foul.
Foul by Kasim Adams (Ghana).
Steve Mounie (Benin) wins a free kick on the right wing.
Jordan Ayew (Ghana) wins a free kick on the left wing.
Foul by Khaled Adénon (Benin).
Jordan Ayew (Ghana) wins a free kick on the left wing.
Foul by Seidou Barazé (Benin).
André Ayew (Ghana) wins a free kick in the attacking half.
Foul by Mama Seibou (Benin).
Attempt missed. Jodel Dossou (Benin) right footed shot from outside the box is too high. Assisted by Mickaël Poté.
Corner, Ghana. Conceded by Fabien Farnolle.
Attempt saved. Thomas Partey (Ghana) right footed shot from outside the box is saved in the top right corner.
Jordan Ayew (Ghana) wins a free kick in the attacking half.
Foul by Khaled Adénon (Benin).
Foul by Mickaël Poté (Benin).
Thomas Partey (Ghana) wins a free kick in the defensive half.
Attempt missed. Jodel Dossou (Benin) left footed shot from outside the box is high and wide to the left. Assisted by Jordan Adeoti.
Foul by Mickaël Poté (Benin).
Africa Cup of Nations: Ayew brothers on target as Ghana draw with Benin